CHEMICAL IDENTIFICATION RTECS NUMBER :EM9800000 CHEMICAL NAME :3-Buten-2-one CAS REGISTRY NUMBER :78-94-4 LAST UPDATED :199806 DATA ITEMS CITED :19 MOLECULAR FORMULA :C4-H6-O MOLECULAR WEIGHT :70.10 WISWESSER LINE NOTATION :1V1U1HEALTH HAZARD DATAACUTE TOXICITY DATA TYPE OF TEST :LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE :Oral SPECIES OBSERVED :Rodent - rat DOSE/DURATION :23100 ug/kg TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value TYPE OF TEST :LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE :Inhalation SPECIES OBSERVED :Rodent - rat DOSE/DURATION :7 mg/m3/4H TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value TYPE OF TEST :LDLo - Lowest published lethal dose ROUTE OF EXPOSURE :Intraperitoneal SPECIES OBSERVED :Rodent - rat DOSE/DURATION :15 mg/kg TOXIC EFFECTS :Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia TYPE OF TEST :LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE :Oral SPECIES OBSERVED :Rodent - mouse DOSE/DURATION :23300 ug/kg TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value TYPE OF TEST :LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE :Inhalation SPECIES OBSERVED :Rodent - mouse DOSE/DURATION :8 mg/m3/2H TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value TYPE OF TEST :LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE :Intraperitoneal SPECIES OBSERVED :Rodent - mouse DOSE/DURATION :76 mg/kg TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value TYPE OF TEST :LDLo - Lowest published lethal dose ROUTE OF EXPOSURE :Oral SPECIES OBSERVED :Rodent - guinea pig DOSE/DURATION :15 mg/kg TOXIC EFFECTS :Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression TYPE OF TEST :LDLo - Lowest published lethal dose ROUTE OF EXPOSURE :Intraperitoneal SPECIES OBSERVED :Rodent - guinea pig DOSE/DURATION :15 mg/kg TOXIC EFFECTS :Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold TYPE OF TEST :TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE :Inhalation SPECIES OBSERVED :Rodent - rat DOSE/DURATION :3900 ppb/6H/9D-I TOXIC EFFECTS :Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - acute pulmonary edema
Related to Chronic Data - death TYPE OF TEST :TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE :Inhalation SPECIES OBSERVED :Rodent - rabbit DOSE/DURATION :7800 ppb/6H/9D-I TOXIC EFFECTS :Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - acute pulmonary edema
Lungs, Thorax, or Respiration - respiratory depression TYPE OF TEST :TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE :Inhalation SPECIES OBSERVED :Rodent - guinea pig DOSE/DURATION :7800 ppb/6H/9D-I TOXIC EFFECTS :Sense Organs and Special Senses (Eye) - conjunctive irritation
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Nutritional and Gross Metabolic - weight loss or decreased weight gainMUTATION DATA TYPE OF TEST :Mutation in microorganisms TEST SYSTEM :Bacteria - Escherichia coli DOSE/DURATION :125 ug/plate REFERENCE :MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 412,17,1998
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993
毒理学数据：
1、急性毒性
大鼠口径LD50: 23100 ug/kg；大鼠吸入LC50: 7 mg/m3/4H
大鼠腹腔LD50: 15 mg/kg
小鼠口径LD50: 23300 ug/kg；小鼠吸入LC50:8mg/m3/2H
小鼠腹腔LD50: 76 mg/kg
猪口径LD50: 15 mg/kg
猪腹腔LD50: 15 mg/kg
2、其他多剂量毒性数据
大鼠吸入TCLO：3900 ppb/6H/9D-I
兔子吸入TCLO：7800 ppb/6H/9D-I
猪吸入TCLO：7800 ppb/6H/9D-I
3、致畸性
沙门氏菌：250 umol/L
大肠杆菌：100 nmol/tube
4.急性毒性[14]
LD50：30mg/kg（大鼠经口）
LC50：7mg/m3（大鼠吸入，4h）
5.刺激性[15] 小鼠经皮：1%，重度刺激。
生态数据：
1.生态毒性[16] EC50：＜10mg/L（绿藻）
2.生物降解性 暂无资料
3.非生物降解性[17] 空气中，当羟基自由基浓度为5.00×105个/cm3时，降解半衰期为21h（理论）。